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This study investigates the complementary effects of side and corner modification strategies for the aerodynamic performance of tall buildings. A total of 81 doubly symmetric models were examined. High-frequency force balance (HFFB) wind tunnel testing was conducted at the University of Florida’s (UF) boundary layer wind tunnel (BLWT), an NSF-sponsored Natural Hazard Engineering Research Infrastructure (NHERI) Experimental Facility. The 81 models were examined under two approach flow conditions, which are suburban and open terrains. For each flow condition, the models were tested under 10 different wind angles from 0° to 45°. The base responses were recorded using a 6-axis load cell. A total of 1620 tests (81 models × 2 flow conditions × 10 wind angles) were performed in the BLWT at UF. Details are provided in the report document. 

The impact of climate change and global warming makes it imperative to seek sustainable solutions for the built environment. To facilitate the design of future sustainable buildings, wind tunnel tests are conducted in this study to investigate the flow characteristics and wind energy potential over a flat building roof with different edge configurations. Specifically, this study addresses the effect of parapet walls and roof edge-mounted solar panels on the wind flow over a flat-roof tall building. The results show that parapet walls generally slow down the wind speed and increase turbulence intensity as well as skewness angle, which compromises the efficiency of traditional turbine-based wind energy harvesting. On the other hand, the presence of solar panels on the roof edge (or on the top of the parapet wall) further alters flow separation and has the potential to enhance wind energy harvesting over the roof, especially for the solar panel inclined at 30°. In addition to providing valuable data for validating computational fluid dynamics (CFD) simulations, this study could also help to guide the design of wind energy harvesting devices on the building roof and explore the promising synergy with solar panels. 

Plasma wakefield acceleration in the nonlinear blowout regime has achieved marked milestones in electron beam acceleration, demonstrating high acceleration gradients and energy efficiency while preserving excellent beam quality. However, this regime is deemed unsuitable for achieving positron acceleration of comparable results, which is vital for future compact electron–positron colliders. In this article, we find that an intense positron beam loaded at the back of beam-driven blowout cavity can self-consistently induce the focusing field and flatten the longitudinal wakefield, leading to stable, high-efficiency, and high-quality positron acceleration. This is achieved through the formation of an on-axis electron filament induced by positron beam load, which shapes the plasma wakefield in a distinct way compared to electron beam load in the blowout regime. Via a nonlinear analytic model and numerical simulations, we explain the novel beam loading effects of the interaction between the on-axis filament and the blowout cavity. High-fidelity simulations show that a high-charge positron beam can be accelerated with >20% energy transfer efficiency, ~1% energy spread, and ~1 mm·mrad normalized emittance, while considerably depleting the energy of the drive beam. The concept can also be extended to simultaneous acceleration of electron and positron beams and high transformer ratio positron acceleration as well. This development offers a new route for the application of plasma wakefield acceleration into particle physics. 

Abstract While significant advances have been made in predicting static protein structures, the inherent dynamics of proteins, modulated by ligands, are crucial for understanding protein function and facilitating drug discovery. Traditional docking methods, frequently used in studying protein-ligand interactions, typically treat proteins as rigid. While molecular dynamics simulations can propose appropriate protein conformations, they’re computationally demanding due to rare transitions between biologically relevant equilibrium states. In this study, we present DynamicBind, a deep learning method that employs equivariant geometric diffusion networks to construct a smooth energy landscape, promoting efficient transitions between different equilibrium states. DynamicBind accurately recovers ligand-specific conformations from unbound protein structures without the need for holo-structures or extensive sampling. Remarkably, it demonstrates state-of-the-art performance in docking and virtual screening benchmarks. Our experiments reveal that DynamicBind can accommodate a wide range of large protein conformational changes and identify cryptic pockets in unseen protein targets. As a result, DynamicBind shows potential in accelerating the development of small molecules for previously undruggable targets and expanding the horizons of computational drug discovery. 

This study proposes a surrogate-based cyber-physical aerodynamic shape optimization (SB-CP-ASO) approach for high-rise buildings under wind loading. Three components are developed in the SB-CP-ASO procedure: (1) an adaptive subtractive manufacturing technique, (2) a high-throughput wind tunnel testing procedure, and (3) a flexible infilling strategy. The downtime of the procedure is minimized through a parallel manufacturing and testing (llM&T) technique. An unexplored double-section setback strategy with various cross-sections and transitions positions is used to demonstrate the performance of the proposed procedure. A total of 173 physical specimens were evaluated to reach the optimization convergence within the reserved testing window. Further analysis of promising shapes considering multiple design wind speeds is suggested to achieve target performance objectives at various hazard levels. Practical information on setback and cross-section modification strategies is discussed based on the optimization results. In comparison with a square benchmark model, the roof drifts for promising candidates with similar building volumes are reduced by more than 70% at wind speeds higher than 50 m/s. This procedure is expected to provide an efficient platform between owners, architects, and structural engineers to identify ideal candidates within a defined design space for real-world applications of high-rise buildings.